9^th Global Veterinary Summit

This study was designed to evaluate the hypolipidimic effect of sitagliptin in Hydrogen peroxide (H2O2)/fructose_ exposed male rabbits. Twenty one (21) adult male rabbits were randomly and equally divided into three groups (T1, T2 and T3) and were treated for 45 days as follows: Group T1 (Control group), rabbits in groups T2 and T3 were given 40% fructose -1% H2O2 in drinking water. In addition to fructose and H2O2, 1.5mg/kg. B.W of sitagliptin were administered orally to rabbits in group (T3). Fasting (8-12 hrs) blood samples were collected by heart puncture technique at 0, 45 days of the experiment for measuring a- Total cholesterol (TC), Triacylglycerol (TAG) and high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C) and very low density lipoprotein-cholisterol (VLDL-C) concentration. In addition to measuring body weight and waist circumference weekly as marker for central obesity. The results revealed that exposure of rabbits to 40% fructose -1% H2O2 in drinking water (T2 group) caused a case of dyslipidemia manifested by ( a significant elevation in serum (TC), (TAG), (LDL-C) and (VLDL-C) concentration. In addition to depression (HDL-C) concentration and a significant elevation in body weight and waist circumference. Hypolipidimic

effect of sitagliptin, was clarified in group (T3), manifested by restoring of previous parameters leading to correction the case of dyslipidemia, body wheat and central obesity. In conclusion, the results of this study confirm the to the ameliorative role of Sitagliptin against deleterious effect of fructose/ H2O2 in adult male rabbits.