Petros Admasu
Jigjiga University
Ethiopia
Title: In vivo antirabies activity evaluation of hydroethanolic extract of roots and leaves of Phytolacca dodecandra
Biography
Biography: Petros Admasu
Abstract
Rabies remains a major cause of death and severe economic impact in Ethiopia regardless of the availability of effective vaccines for its control. Where rabies vaccines are physical inaccessible and economically unaffordable, folk drugs is an option for rabies treatment in different areas of Ethiopia. Phytolacca dodecandra is used widely for traditional treatment of rabies. The study was undertaken to evaluate antirabies activity of hydroethanolic extract of roots and leaves of P.dodecandra by using mice model. All groups of mice challenged with rabies virus (CVS-11) containing 50-200MIMLD50 at day 0. Treatment groups of mice were orally administered with dose of 300, 600 and 1000 mg/kg of both parts of the plant extract dissolved with 1ml distilled water for seven consecutive days after an hour of CVS challenge. Control group of mice only administered with distilled water as placebo. Comparison of group of mice made based on the difference in survival rate and period (days). The result showed all doses of roots and, 300 and 600mg/kg doses of leaves of the plant extract didn’t significantly (P>0.05) increase the survival period of mice compared to the control group. However, 1000 mg/kg dose of leaves of the plant extract was significantly (P<0.05) increased the survival period of mice as compared to control group. Though the finding indicated the existence of some antirabies activity in extract of leaves of P.dodecandra at higher dose, the plant didn’t safe mice from deaths. Further research (elucidating its active principles) is needed before using the plant to treat rabies.